Structural and Functional Alterations of the Gut Following ‎Lincomycin Usage: ‎Evaluating the Risks in the Libyan ‎Pharmaceutical Market

Purpose: The present study aimed To investigate the neuroinhibitory and dysregulatory effects of lincomycin on visceral nervous ‎regulation and gastrointestinal motor function via the gut-brain axis in a rat model.‎

Materials and Methods: Twenty adult white laboratory rats were orally administered lincomycin hydrochloride (84 ± 10 ‎mg/kg/day) for 9 to 14 days. Morphological and neurophysiological parameters of the ‎gastrointestinal tract were subsequently evaluated‎.

Results: ‎ Lincomycin treatment induced severe intestinal dysbiosis characterized by profound disruption ‎of the microbial flora. Morphological examination revealed significant cecal enlargement and ‎pronounced gaseous distension throughout the gastrointestinal tract. These structural alterations ‎were accompanied by marked suppression of mesenteric neural responses and paradoxical ‎hyperactivation of colonic contractile power, reflecting a segmental neural mismatch between ‎the upper and lower gastrointestinal regions.‎‎

Conclusion: Lincomycin-induced dysbiosis drives pathological cecal expansion and intestinal bloating, ‎which significantly contribute to neural mismatch along the gut-brain axis, manifesting as ‎neuroinhibitory and motor dysregulatory effects between upper and lower gastrointestinal ‎segments‎. (Open J Biomed Res 2026;5:43-46)